SynBio4Flav
Providing a path for the standardized production of flavonoids
By using synthetic biology, the SynBio4Flav project aims to provide a cost-effective alternative to current flavonoid production. SynBio4Flav’s scientific challenge is to produce flavonoids by breaking down their complex biosynthetic pathways into standardized specific parts, which can be transferred to engineered microorganisms within Synthetic Microbial Consortia to promote flavonoid assembly through distributed catalysis. SynBio4Flav’s groundbreaking approach has great potential beyond the production of flavonoids. The project’s ultimate goal is to deliver a paradigm shift in biotechnological manufacturing of complex natural chemicals.
Flavonoids are phytonutrients occurring naturally in plants. Thousands of flavonoids have been identified, each with its unique set of bioactivities that may be important for health benefits. Flavonoid-rich foodstuffs include parsley, onions, berries, black tea, green tea, oolong tea, all citrus fruits, bananas, sea-buckthorns, buckwheat, Ginkgo biloba, red wine and dark chocolate. Depending on the type they can exhibit anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties. They could also support our immune and cardiovascular systems and help to modulate key functions of enzymes in our cells.
Flavonoids are used in numerous applications including functional food & beverages, dietary supplements, cosmetics, and pharmaceuticals. Despite the growing market demand for flavonoids, current production is constrained by conventional manufacturing processes using plant-based sources. Furthermore, their production remains elusive to chemical synthesis and biotech-based approaches.
‘CONVERSATIONS ON METABOLIC ENGINEERING: TOWARDS A NEW PARTNERSHIP WITH NATURE’
The second in our series of conversations on the topic of ‘Metabolic Engineering’. We brought together experts from complex systems, regenerative architecture, molecular microbiology and science journalism to discuss metabolic engineering in a partnership with nature. Watch here >>>
#FridayEveningScience and #AmateurJournalism. @Jnogales_SBG interviewed by a #PrimaryStudent. Discussion touches #flavonoid production using #MicrobialConsortia, #HeavyMetal and many other cool topics!😎👩🔬🧑🔬🇪🇺
#11F un día para promover la presencia de la mujer en la ciencia y las vocaciones científicas en niñas. En la foto de ayer, faltan muchas investigadoras del CNB que han acudido a contar su trayectoria y ciencia a centros educativos #TodasHacemosCiencia #CNBerAs #365Días11F
Insights into #flavonoid production using #microbialconsortia with @Jnogales_SBG at the annual workshop of @CNB_CSIC's department of #SystemsBiology 👇🏿
Our first biorreactor already in place thanks to @Bioprocess_Tech, @susplast, it's designed to address distributed catalysis. Exciting times ahead for @SynBio4Flav, @MixUp_H2020, @PromiconH2020
Golden Standard: Finally ready for share via @SEVAplasmids. Order your GS kit for modular DNA assembly beyond E. coli. Thanks @polybiogroup @MixUp_H2020 @SynBio4Flav https://t.co/4dbV9dQloK
Fran Canalejo proudly representing @SynBio4Flav at @CNB_CSIC's #30_CNBWORKSHOP ☺👇🏿👇🏿
Interested in double expression vectors, enzymatic flavonoid glucosylation cascade optimization, including immobilization? Find out our fresh paper! @impopapabilia @SynBio4Flav @UPWr_edu
Evaluation of double expression system for co-expression and co-immobilization of flavonoid glucosylation cascade
Applied Microbiology and Biotechnology - Glucosylation cascade consisting of Leloir glycosyltransferase and sucrose synthase with in situ regeneration...
link.springer.com
@SynBio4Flav project meeting in @UPWr_edu Wroclav for 2 days. More results and many more papers. Please also check out our podcast “Made by Microbes “ on https://open.spotify.com/show/2uVGGrX31pUFr0aEuV3A2o project lead @Jnogales_SBG
@SynBio4Flav further update - MICROBIAL MIXED CULTURES - here #Press Release https://synbio4flav.eu/news/multicultural-microbial-factories/ #flavonoids #synbio #bioreactor
Best group picture background ever in Wroclaw @SynBio4Flav @UPWr_edu https://twitter.com/BarbaraImhof3/status/1578331331100278785
@SynBio4Flav meeting continues with short breaks for photo shootings. Progress Meeting 7 at @UPWr_edu nearly has come to an end… stay tuned for further updates.