Providing a path for the standardized production of flavonoids

By using synthetic biology, the SynBio4Flav project aims to provide a cost-effective alternative to current flavonoid production. SynBio4Flav’s scientific challenge is to produce flavonoids by breaking down their complex biosynthetic pathways into standardized specific parts, which can be transferred to engineered microorganisms within Synthetic Microbial Consortia to promote flavonoid assembly through distributed catalysis. SynBio4Flav’s groundbreaking approach has great potential beyond the production of flavonoids. The project’s ultimate goal is to deliver a paradigm shift in biotechnological manufacturing of complex natural chemicals.


Flavonoids are phytonutrients occurring naturally in plants. There are over 6,000 types of flavonoids, each with its unique set of benefits. Flavonoid-rich foodstuffs include parsley, onions, berries, black tea, green tea, oolong tea, all citrus fruits, bananas, sea-buckthorns, buckwheat, Ginkgo biloba, red wine and dark chocolate. Flavonoids have incredible health benefits. Depending on the type they can exhibit anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties. They also support our immune and cardiovascular systems and help to modulate key functions of enzymes in our cells.
Flavonoids are used in numerous applications including functional food & beverages, dietary supplements, cosmetics, and pharmaceuticals. Despite the growing market demand for flavonoids, current production is constrained by conventional manufacturing processes using plant-based sources. Furthermore, their production remains elusive to chemical synthesis and biotech-based approaches.

Happening now in Madrid! @Jnogales_SBG discusses @SynBio4Flav's approach to produce & screen flavonoids displaying anti-SARS-CoV-2 activity at @CSIC's webinar on in-house #COVID19 research

"#Systems and #Synthetic #Microbiology beyond borders", a #SI in @MicrobialBiote1 @wileymicrobio edited by @claudiaevickers @karthikraman @Himanshu_IITM & yours truly. Read more about the SI and submit your work here:

First glance at the storyboard of our upcoming project vid starring #synbio flavonoids👨🏾‍🔬🎥🎞️➡️🌍
Well done LSG!

El Centro Nacional de Biotecnología @CNB_CSIC es un centro de referencia mundial en la investigación de coronavirus. Está trabajando en el desarrollo de una vacuna por dos vías distintas pero complementarias, además de estudiar antivirales y anticuerpos.

Still steaming hot from @chalmersuniv 👨🏾‍🔬🖥️genome-scale metabolic model (GEM) for Streptomyces albus

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