Providing a path for the standardized production of flavonoids

By using synthetic biology, the SynBio4Flav project aims to provide a cost-effective alternative to current flavonoid production. SynBio4Flav’s scientific challenge is to produce flavonoids by breaking down their complex biosynthetic pathways into standardized specific parts, which can be transferred to engineered microorganisms within Synthetic Microbial Consortia to promote flavonoid assembly through distributed catalysis. SynBio4Flav’s groundbreaking approach has great potential beyond the production of flavonoids. The project’s ultimate goal is to deliver a paradigm shift in biotechnological manufacturing of complex natural chemicals.


We are happy to be able to give visitors the opportunity to better understand the SynBio4Flav project with our virtual exhibition. While we cannot host a public exhibition, we present the main features of the SynBio4Flav Project online, with animations, quizzes, and introducing visitors to the laboratories, research centres and studios of the partners. When we can host something publicly, we can’t wait to show you some of this work in situ, but in the meantime, join us for another kind of distributed experiment filled with discussion, education, inspiration and science!

Flavonoids are phytonutrients occurring naturally in plants. Thousands of flavonoids have been identified, each with its unique set of bioactivities that may be important for health benefits. Flavonoid-rich foodstuffs include parsley, onions, berries, black tea, green tea, oolong tea, all citrus fruits, bananas, sea-buckthorns, buckwheat, Ginkgo biloba, red wine and dark chocolate.  Depending on the type they can exhibit anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties. They could also support our immune and cardiovascular systems and help to modulate key functions of enzymes in our cells.

Flavonoids are used in numerous applications including functional food & beverages, dietary supplements, cosmetics, and pharmaceuticals. Despite the growing market demand for flavonoids, current production is constrained by conventional manufacturing processes using plant-based sources. Furthermore, their production remains elusive to chemical synthesis and biotech-based approaches.


¿Tienes planes para la #NocheEuropeaInvestigadores? Los centros CSIC de Cantoblanco ofrecemos actividades virtuales para centros escolares y público general el 27 de Noviembre, encuentra la tuya 😊 👩‍🔬🧑‍🔬
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Cell ageing can be slowed by oxidants. ​At high concentrations, #oxidants are harmful to cells in all organisms and have been linked to #ageing. But a study from Chalmers University has now shown that it is possible to slow down the ageing of #yeastcells.

Fab day for project dissemination! @CNB_CSIC's Erika González delivers an online workshop on #flavonoids for primary students at #SemanaCienciaInnovacion2020

Before closure, #ASBEV last afternoon is followed by two fascinating keynote talks; Marileen Dogterom @MarileenD from @tudelft gives a lecture on building a synthetic cytoskeleton and Jef Boeke @JefBoeke from @nyugrossman on the dark matter and engineering of the genome. #synbio

A short overview of the last 20 years of #SynBio and its exponential advance! The importance of SynBio for the development of current #openscience initiatives was also discussed! #eusynbios2020

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